More Emotionally Calm
Release the heavy weight of guilt and overthinking.
Author: Mathew, Sanjay J.
Brand: Adis
Edition: 1st ed. 2016
Binding: Hardcover
Number Of Pages: 174
Release Date: 15-12-2016
Part Number: 3 Tables, color; 3 Illustrations, color;
Details: This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants.
Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic moleculartargets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose.
This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.
EAN: 9783319429236
Package Dimensions: 9.3 x 6.4 x 0.4 inches
Languages: English
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Are You...
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Frequently Asked Questions
No. This is a digital PDF workbook that you can download immediately after purchase. No physical product will be shipped.
The 7-Day Guilt Reset Workbook is a digital self-help guide designed to help you understand feelings of guilt, reflect on your experiences, and build healthier thought patterns through simple daily exercises.
The workbook is designed to be completed over seven days, with each day's activities taking approximately 10–15 minutes. You can also work through it at your own pace.
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By completing the workbook, you'll gain a better understanding of your feelings of guilt, learn practical techniques to manage self-blame and overthinking, and develop healthier habits that support self-forgiveness and emotional growth.
